Review In the first post, I described some background information on computer storage, how byte arrangement “endianness” can impact our tools, and ASCII vs binary data. In the previous post, I discussed the 3-bit format I used for this evaluation. Let me summarize the approach and then we’ll proceed to …
This post will begin to describe the “Proof of Concept” work (or play I guess) I have done to explore two primary ideas: What impact will a terse binary format of the human genome have on file compression and pattern matching processing speed? If we use a binary format, what will be …
This and subsequent posts will discuss the advantages of storing and processing Genomic data in a binary format vs ASCII. We will begin at a very high level and dive deep to using binary processing at the lowest level in the computer system. Feel free to skip this introduction if …
The promises of Personalized Medicine are exciting: using our genetic makeup and known outcomes, providers will be able to offer a customized treatment plan instead of just using a population health approach. There are challenges: Datasets are large. The human genome is comprised of over 3 billion “base pairs” of …