Binary for Dummies: Explaining Endianness and Base Counts in the Simplest Way Possible

I’ve received feedback that this binary stuff is too complex to understand.  So let me start at the very foundation and build up from there. In this post, I’ll talk about how we can use a smaller set of binary digits to represent large counts (aka “numbers”) and to illustrate …

Genomic Data: Binary vs ASCII – Part Three: CPU vs GPU

Review In the first post, I described some background information on computer storage, how byte arrangement “endianness” can impact our tools, and ASCII vs binary data. In the previous post, I discussed the 3-bit format I used for this evaluation.  Let me summarize the approach and then we’ll proceed to …

Thoughts and Solutions for Processing Large Genomic and Other Datasets

The promises of Personalized Medicine are exciting:  using our genetic makeup and known outcomes, providers will be able to offer a customized treatment plan instead of just using a population health approach. There are challenges: Datasets are large. The human genome is comprised of over 3 billion “base pairs” of …